An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that targets motor neurons, leading to paralysis and Games death within a few years of disease onset.While several genes have been linked to the inheritable, or familial, form of ALS, much less is known about the cause(s) of sporadic ALS, which accounts for approximately 90%